Melatonin spray

Melatonin spray is a natural aid containing the "sleep hormone" and extracts of the herbs mint and valerian in the form of a spray to be injected under the tongue. The combination of the three ingredients has a beneficial effect on the human body and in synergy with each other, having a beneficial effect on achieving calm and quality sleep.

Product Content

Main ingredients: Ingredients: Mentha (Mentha) extract, valerian (Valeriana officinalis) extract, melatonin, purified water, ethanol.

• One spray: 0.3 ml
• Quantity: 30 ml
• Packaging for: 100 days

In one injection – water-ethanol extract (16%):

• Melatonin - 1 mg
• Mint extract - 4 mg
• Valerian extract - 2 mg

We offer pure and natural support for your health:

• 100% active ingredients
• Vegetarian formula
• Gluten free
• Lactose free
• No added sugar
• Without preservatives and artificial colors
• Not tested on animals.

Recommended intake

Recommended daily intake

• Spray once under the tongue, once a day - in the evening 30 minutes before sleep.

Recommended intake period

• Take this product as needed.
• Continuous intake leads to rapid habituation.

Other recommendations:

• For oral use only.
• Do not exceed the recommended daily dose.
• Not to be taken by pregnant and lactating women.
• The product is not a substitute for a varied diet.
• The product is not a medicine, but a food supplement.
• Consult your personal physician before admission.

Who is it suitable for?

The product is suitable for anyone who has difficulty falling asleep or restless sleep.

It is also a good choice for people who have limited time to sleep - so they will ensure faster falling asleep and entering the REM-phases of sleep, where the perfect regenerative processes take place.

It has a general strengthening, soothing and mild sedative effect. It exhibits an antioxidant effect, as well as a protective effect on the central nervous system (CNS).

It prevents various neurodegenerative diseases and is a good choice for adjunctive treatment in people in the early stages of Alzheimer's disease and dementia.

The trust of our customers is important to us. Therefore, each product has a registration number issued by the Agency responsible for the control of food and food additives, which verifies its authenticity and quality: T032304821

GMP certificate

GMP certificate - Good Manufacturing Practice - represents the gold standard in the production of nutritional supplements.

VitaOn products are manufactured following strict production processes and strict control at every stage, guaranteeing high quality and safety.

GMP certificates are a kind of proof of our company's dedication to providing you with only first-class premium products.

We prioritize consistency, accuracy and cleanliness and thus offer you peace of mind and trust that we are responsible for.

What is melatonin?

Melatonin, or as it is also known as the "sleep hormone", is a substance that by its chemical nature is indoleamine. Indolamines are a group of similar compounds that act as neurotransmitters in the CNS.

Melatonin in vertebrates, including humans, performs the primary function of regulating sleep and wakefulness. It is also responsible for regulating blood pressure and rhythmic seasonal changes in animals.

It exerts most of its functions by activating specific receptors, and others by its role as an antioxidant.

Melatonin is a natural neurotransmitter and hormone that our body produces.

Deficiency symptoms are associated with sleep and circadian rhythm disturbances. They are observed most often in people working in shifts, in which the natural biological clock is disturbed. They are also common in the elderly.

In case of deficiency, melatonin is taken as a food supplement in the form of tablets, drops or spray.

Interesting facts about melatonin

The origin of the word melatonin has Greek roots and means "melas" - black and "tonos" - suppress.

Melatonin gets this name in relation to its mechanism of action, by which it was first discovered. In 1917, scientists KP McCord and FP Allen discovered that feeding tadpoles bovine pineal gland extract lightened their color by contracting the dark epidermal melanophores.

The effect of "whitening" the skin has also been proven in humans, and later its connection with the regulation of the circadian rhythm was also established.

Melatonin is a light-dependent hormone. It is produced at night, when there are no light sources, in a small endocrine gland called the pineal gland. It is located in the central part of the brain, but outside the blood-brain barrier.

The production of this hormone is under the control of the suprachiasmatic nuclei, which receive light/dark information from the retinal photosensitive ganglion cells. They are located in the eye.

Melatonin stimulates the activity of nocturnal animals, while in diurnal animals it stimulates sleep and the process of falling asleep.

In the animal kingdom, melatonin influences reproductive periods and the hormonal changes that occur during this time. They stimulate or suppress the libido, regulate the change of coat and others.

In humans, melatonin controls metabolism by lowering leptin at night.

Biological synthesis

The process of producing melatonin involves a series of biochemical reactions.

The main precursor of melatonin, as well as other neurotransmitters (serotonin and others), is the amino acid L-tryptophan. This amino acid is indispensable for the human body and we obtain it through food during the protein breakdown process.

Next, the indole ring in the tryptophan structure undergoes a hydroxylation process by an enzyme called tryptophan hydroxylase, producing 5-hydroxytryptophan (5-HTP). 5-HTP is a precursor to both melatonin and serotonin.

5-HTP then undergoes decarboxylation by pyridoxal phosphate and 5-hydroxytryptophan decarboxylase to produce serotonin.

Depending on the time of day and the needs of the body, serotonin can begin to fulfill its specific needs or become N-acetylserotonin with the help of serotonin N-acetyltransferase and acetyl-CoA.

After undergoing a process of methylation of the hydroxyl group of acetylserotonin by hydroxyindole O-methyltransferase and S-adenosyl methionine, it is converted into melatonin.

The chemical name of melatonin is N-acetyl-5-methoxytryptamine.

Regulation and rhythmicity in melatonin secretion

Melatonin secretion is a rhythmic process associated with wakefulness and sleep, day and night.

It is a completely hormonal signal, conditioned by the presence of light and independent of behavioral factors. It is regulated by the release of norepinephrine from sympathetic nerve fibers only at night.

Norepinephrine increases levels of cyclic adenosine monophosphate (cAMP) via beta-adrenergic receptors and activates an enzyme called cAMP-dependent protein kinase A. This biochemical pathway is crucial for the regulation of the enzyme arylalkalamine-N-acetyltransferase (AANAT), which is of great importance for the synthesis of melatonin.

During the day, in the presence of a light stimulus and the absence of norepinephrine stimulation, this protein is rapidly destroyed by proteosomal proteases and thus the synthesis of melatonin is inhibited.

At night, the rise in norepinephrine leads to an accumulation of cAMP, which in turn increases the synthesis of AANAT and signals our pineal gland to start releasing melatonin. This process is inhibited by the presence of light.

Benefits of melatonin for the human body

The main function of melatonin is the regulation of the circadian rhythm and the wake-sleep mode through a number of complex biochemical and biophysical reactions.

In newborns, melatonin levels normalize and become constant until around three months of age, being highest between midnight and 8am.

As you enter your teenage years, melatonin release begins later in the evening, which results in later falling asleep and longer sleep.

Advancing age has an inversely proportional relationship with the processes of melatonin secretion. Older people secrete small amounts of this hormone, which is why they usually spend much less time sleeping.

Clinical studies prove that people with reduced production or diseases in which there is a deficiency of melatonin benefit from taking it in the form of a food supplement such as tablets, capsules or spray.

Benefits of melatonin as an antioxidant

Melatonin has the function of a powerful antioxidant. This function of his was proven in 1993.

It actively participates in the neutralization of free oxygen and nitrogen radicals, and it has also been proven to increase the activity of a number of antioxidant enzymes.

The antioxidant properties of melatonin make it good at protecting against lipid oxidation by stabilizing biological membranes. It is effective against the action of ionizing radiation, poisoning with heavy metals and neutralization of waste products from the metabolism of medicinal preparations.

This hormone has been shown to protect DNA from oxidative stress as well as cellular proteins.

When the DNA code is broken as a result of strong oxidative stress, non-functional proteins or those with a harmful effect begin to be produced. As a result, the probability of the occurrence of oncological diseases and abnormalities increases.

Melatonin exhibits the ability to modulate redox-sensitive targets whose structures and functions are disrupted even by minimal exposure to oxidative stress, and responds even to sub-oxidative stimuli.

Melatonin demonstrates synergistic action with other antioxidants such as vitamin C, provitamin A and tocopherols such as vitamin E and polyphenolic organic compounds.

Melatonin intake is associated with increased plasma antioxidant capacity. Several metabolites of melatonin metabolism also show antioxidant potential.

Melatonin Anti-Aging Benefits

It has been established that as the aging process progresses, disorders in melatonin synthesis are observed. Quantitative and qualitative changes are strictly individual, but the decrease in the levels of melatonin and its metabolites are mainly found in specific areas of our body.

Decreases in its levels are associated with various neurovegetative diseases, such as Alzheimer's disease and various forms of senile dementia. They are a consequence of disruption of the functionality and structure of the suprachiasmatic nucleus, impaired neuronal transmission in the pineal gland, as well as formation of calcifications in the gland.

In conclusion, science accepts that melatonin may be beneficial in the treatment of pathological conditions associated with aging. Adding it to compensate for the deficiencies could restore the body's normal homeostasis.

It is also known that melatonin inhibits the processes of internal apoptosis (cell death), which are accelerated in neurovegetative diseases such as Parkinson's disease, amyotrophic lateral sclerosis and others.

Early administration of melatonin in Alzheimer's disease both reduces damage caused by oxidative stress and reduces the accumulation of amyloid bodies.

In all neurodegenerative diseases, behavioral changes are observed that are a consequence of neuronal damage. Taking melatonin can stabilize these conditions by preventing cholinergic system dysfunction from occurring. Acetylcholine is the leading neurotransmitter in it.

If therapy is started in time already in the first stages of the clinical manifestation of Alzheimer's disease, this hormone can slow down its development and reduce the symptoms.

Most of the neuroprotective properties and anti-aging effects of melatonin are due to the powerful antioxidant properties of this indoleamine. They have a beneficial effect in the treatment of this type of diseases of the central nervous system. They reduce the rate of apoptosis, reduce fat peroxidation induced by beta-amyloid protein and increase the capacity of DNA to repair itself.

Benefits of melatonin for the liver

Melatonin is found in many plant species, in which it performs various functions. The benefits for the human body from its intake have been proven in a number of conditions.

An interesting fact is that although it is called the sleep hormone, melatonin is also found in large doses in coffee, a drink that has been used for centuries to deal with fatigue, sleepiness and to increase the mental and physical capacity of the body.

That's why some people report that after taking coffee they actually become sleepy instead of invigorated.

Taking coffee, thanks to its content of melatonin, as well as other natural antioxidants, has a hepatoprotective effect on the liver. These effects have been demonstrated in liver diseases such as fibrosis, steatohepatitis and cirrhosis secondary to carbon tetrachloride poisoning.

A number of other studies confirm the benefits of taking this indoleamine to preserve liver function.

Melatonin benefits for the heart

Positive effects of additional melatonin intake or increased plasma levels are also observed on the cardiovascular system.

It is a well-known fact that the intake of red wine has a protective effect on heart diseases. One reason is that red wine inhibits the melatonin receptor, thereby increasing the concentration of the free-circulating hormone in the blood.

Taking melatonin as a supplement or through food leads to a reduction in right ventricular hypertrophy, improved pumping function and reduced cardiac interstitial fibrosis.

Benefits of melatonin as a means of fighting cancer cells

A number of studies have shown that melatonin may have a role as an anti-cancer agent. An inverse relationship between some oncological diseases and serum melatonin levels and melatonin receptor expression has been demonstrated.

Antiproliferative activity (ie, the ability to suppress the division of malignant cells) has been established against several tumor cell populations.

These populations include:

• Breast cancer
• Colon carcinoma
• Vaginal
• Endometrial
• Pulmonary
• Pancreatic
• Prostatic
• Renal
• Testicular and others.

The action of melatonin is related to its ability to reduce DNA damage, increase the activity of other antioxidant enzymes and regulate the expression of specific oncogenes. In experimental studies, this hormone works synergistically with a number of chemotherapy drugs.

The role of melatonin in the prevention and prevention of cancers has been indirectly proven by finding that the incidence of certain specific cancers is significantly higher in certain groups of people.

What they all have in common is a disrupted circadian rhythm and exposure to light at night. Thus, the biological rhythm of peaks and troughs in serum melatonin levels is completely confused and it cannot perform its regulatory functions.

This is a prerequisite for:

• Repeatedly increased oxidative stress
• Impaired immunological response to stressors
• Increased proliferation and reduced apoptosis of cells with defective DNA helix and others.

Mint (Mentha Piperita)

Mint (mentha piperita) is a green shrubby plant, a member of the Lamiaceae family. Also known as the mint family, it includes a large number of aromatic herbs, including basil, rosemary, oregano, and gentian.

It is a low perennial plant that has a wide area of distribution. It likes to inhabit moist and slightly sunny places, most often around rivers, natural and artificial reservoirs.

Active substances of peppermint

Mint is an aromatic herb known for its essential oils. They are extracted by alcoholic distillation of the leaf mass of the plant.

The period in which the leaves of the herb are harvested for the purpose of extracting the aromatic oil is at the beginning of the flowering phase. Then the oil is the richest in active substances. Mint extract is standardized and by law must contain no less than 44% menthol, 15-30% menthone, 5% esters and numerous terpenoids.

Also contains:

• Flavonoids (up to 12%)
• Polyphenols
• Carotenes
• Tocopherol
• Choline
• Betaine.

Peppermint essential oil contains the terpenoids alpha-pinene and beta-pinene, alpha-phellandrene and also acetic and isovaleric acid esters. The latter two compounds are responsible for peppermint's strong antimicrobial action.

Mint and peppermint oil are widely used in both the food and pharmaceutical industries. It has many useful properties and is therefore widely used in folk and traditional medicine.

It helps with various conditions such as:

• Hot flashes in women nearing menopause
• Irritable Bowel Syndrome (Irritable Colon)
• Herpes simplex virus infections
• States of anxiety and worry
• Mental loads
• Nausea and indigestion.

Benefits of peppermint on the nervous system

Peppermint has been used for years in traditional and folk medicine for its calming effect. Its essential oils soothe the brain and help achieve a state of relaxation.

Taking mint extract before going to bed contributes to the faster "turning off" of thought processes, thus contributing to faster falling asleep.

Taken during the day, peppermint extract stimulates the release of serotonin and helps to improve mood, relieve anxiety and help with conditions of mild subclinical depression.

Other benefits of taking mint for the human body

Peppermint is effective in relieving various symptoms related to the gastrointestinal tract, cramps, bloating. Improves digestion. Relieves inflammatory conditions of the intestinal and gastric mucosa.

Mint also has analgesic properties, or to put it another way - it has a pain-relieving effect. It is mediated through the activation of the κ-opioid receptor, blocking the transmission of pain signals.

Proof of the effects of mint in the treatment of irritable bowel syndrome is also provided by a Cochrane study from 2006, which confirmed that 79% of patients with this disease reported a significant reduction in pain symptoms after 2 weeks of taking an extract of the herb.

Due to the similarity in the receptors that are expressed throughout the gastrointestinal tract, mint extract exhibits an antispasmodic effect in biliary colic, intestinal colic, stomach cramps. It also affects the smooth muscles of the uterus, with women benefiting from this effect during a painful cycle.

Valeriana (Valeriana Officianalis)

Valeriana, or valerian, is a perennial flowering plant native to Europe and Asia. Its Latin name is Valeriana Officinalis.

Known since ancient times, at least since the time of the ancient Greeks and Romans, this plant was widely used in folk medicine. Hippocrates and Galen described its properties as a sedative and prescribed it for insomniacs.

At present, the root of the plant is most often used, and an extract is prepared from it. It has a calming effect and removes anxiety.

The content of valerian extract is extremely rich in active chemical substances. Some of them have been studied and their action is proven and known, and another part of them is still in the process of research.

Active substances in valerian extract

Valerian root is extremely rich in active substances divided into several groups.

These groups include:

• Alkaloids - actinidin, hatinine, siantine, valerine and valerianine
• Isovaleramides
• Gamma-aminobutarate (GABA)
• Isovaleric acid
• Iridoids, including valepotriates: isovaltarate and valtarate
• Sesquiterpenes - valeric acid, hydroxyvaleric acid and acetoxyvaleric acid
• Flavonones - hesperidin, 6-methylapigenin and linarin

Benefits of valerian supporting the action of Melatonin spray

Valerian is a well-studied herb. It is clear to science that behind its benefits related to sleep and the relaxation of the body, there are specific substances belonging to some of the groups listed above. These are the substances isovaleramide and valeric acid.

Benefits of Isovaleramide for Sleep and the Nervous System

Isovaleramide is an organic compound derived from isovaleric acid. It is contained precisely in the extract of the root of the plant. Its action in small doses is to reduce anxiety, and in larger doses it can act as a mild sedative.

This substance is active in the CNS and crosses the blood-brain barrier.

It is a positive allosteric modulator of the GABAa receptor. This means that it binds to another allosteric center of the receptor, potentiating and enhancing the action of the main ligand, in this case - Gamma-aminobutyric acid.

It has a depressant effect on the CNS and is important for the processes of falling asleep. In this way, isovaleric acid has been proven to lead to faster falling asleep and longer and quality sleep.

The interesting thing about it is that it blocks the enzyme that processes alcohol, namely alcohol dehydrogenase. This feature is important and should be considered when consuming alcohol and taking melatonin spray or other products containing valerian.

Valerian acid

This organic acid is a compound from the sesquiterpene group. It is one of the main ingredients of valerian essential oil.

Valeriana has been used since ancient times as a natural sedative and hypnotic, which, in addition to isovaleramide, is due to valeric acid.

Two other valeronic acids, hydroxyvaleronic and acetoxyvaleronic, also contribute to these properties of the herb. Often nutritional supplements and valerian root extracts are standardized to contain a certain amount of valeronic acid (usually 0.8% by weight).

Valeronic acid acts as a subtype-selective GABA receptor positive allosteric modulator, re-enhancing the action of gamma-aminobutyric acid.

This acid also binds to another receptor, this time serotonin. It is about 5-HT. Valeronic acid, when binding to this receptor, acts as a partial agonist (that is, enhances the action of the substance).

Unlike the GABA receptor, which strictly regulates the transmission of only gamma-aminobutyric acid, the serotonin receptor has a regulatory effect on a number of other neurotransmitters.

It is also involved in the regulation mechanisms of the sleep-wake cycle. That is why valeronic acid has a sedative and calming effect, acting on two receptors responsible for similar functions and processes.

What are the benefits of VitaOn's Melatonin Spray?

In our product, we have carefully selected the ingredients to work absolutely synergistically in their mission to give you a long, quality, truly relaxing sleep.

We have selected a liquid form of all three ingredients that complement each other in their action. This gives you the advantage of faster and easier absorption and, accordingly, faster onset of the desired effects.

Our product will be your means to deal with busy everyday life, because it will ensure a deep and fulfilling sleep. Its intake guarantees maintenance of optimal energy levels throughout the day and a sense of well-being.

For your convenience, we offer a formula that is applied as an oral spray. For its creation we have used only premium extracts of the herbs mint and valerian.

Frequently Asked Questions

Is melatonin suitable for children?

No, the child's organism has a much better regulation of sleep-wake processes than that of an adult. Going to bed and getting up at the same time greatly optimizes melatonin levels in children.

Does melatonin sleep spray really work?

Yes, melatonin sleep spray helps you relax and fall asleep faster. In addition, in the long term, melatonin supplementation leads to a number of other benefits for our health, especially when it comes to our nervous system.

How fast does the melatonin spray work?

When sprayed under the tongue, provided the lights are off and the irritants are removed, the product works for about 10-15 minutes.

How should I take melatonin spray for sleep?

It is best to take it in full preparation for sleep - when we have laid down in peace, turned off the lights and removed possible sound and light irritants.